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      View (26) other PARP antibodies

      Invitrogen

      PARP Monoclonal Antibody (123)

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      Antibody target was verified by KnockDown to ensure the antibody binds to the antigen stated. View details.

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      Catalog #:436400

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      Product Details

      TESTED APPLICATIONS DILUTION
      Immunocytochemistry (ICC) 1-2 µg/ml
      Immunofluorescence (IF) 1-2 µg/ml
      Immunohistochemistry (Paraffin) (IHC (P)) 1:10-1:50
      Immunoprecipitation (IP) Assay Dependent
      Western Blot (WB) 1-3 µg/ml
      PUBLISHED APPLICATIONS
      Miscellaneous PubMed (MISC) See 3 publications below
      Immunoprecipitation (IP) See 1 publications below
      Tested Species reactivity Dog, Horse, Human, Mouse, Rhesus monkey, Rat
      Published species reactivity Human
      Host / Isotype Mouse / IgG1
      Class Monoclonal
      Type Antibody
      Clone 123
      Immunogen Recombinant protein derived from the C-terminal region of human PARP protein.
      Conjugate Unconjugated
      Form Liquid
      Concentration 0.5 mg/ml
      Purification Protein A
      Storage buffer PBS, pH 7.4
      Contains 0.1% sodium azide
      Storage conditions -20°C
      RRID AB_2532215

      Background/Target Information

      This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (4)

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      Bioinformatics

      Protein Aliases: ADP-ribosyltransferase (NAD+; ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1; ADP-ribosyltransferase 1; ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT 1; ADPRT1; ARTD1; msPARP; NAD(+) ADP-ribosyltransferase 1; pADPRT-1; PARP-1; poly (ADP-ribose) polymerase 1; poly (ADP-ribose) polymerase family, member 1; poly (ADP-ribose) polymerase); Poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) polymerase PARP-1; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; Poly[ADP-ribose] synthase 1; poly[ADP-ribose] synthetase 1; PPOL

      Gene Aliases: 5830444G22Rik; Adprp; ADPRT; ADPRT 1; ADPRT1; AI893648; ARTD1; C80510; pADPRT-1; PARP; PARP-1; PARP1; PPOL; sPARP-1

      UniProt ID: (Human) P09874, (Rat) P27008

      Entrez Gene ID: (Dog) 490385, (Human) 142, (Rhesus monkey) 698806, (Rat) 25591, (Mouse) 11545

      Molecular Function: DNA binding protein DNA ligase ligase nucleic acid binding

      Function(s) Blue Arrow Icon
      negative regulation of transcription from RNA polymerase II promoter nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding double-strand break repair via homologous recombination lagging strand elongation DNA repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion double-strand break repair transcription from RNA polymerase II promoter protein ADP-ribosylation cellular response to DNA damage stimulus mitochondrion organization transforming growth factor beta receptor signaling pathway positive regulation of cardiac muscle hypertrophy protein autoprocessing protein sumoylation signal transduction involved in regulation of gene expression macrophage differentiation mitochondrial DNA metabolic process cellular response to insulin stimulus nucleotide-excision repair, DNA incision cellular response to oxidative stress protein modification process DNA damage response, detection of DNA damage mitochondrial DNA repair positive regulation of transcription from RNA polymerase II promoter DNA ligation involved in DNA repair positive regulation of SMAD protein import into nucleus protein poly-ADP-ribosylation global genome nucleotide-excision repair regulation of cellular protein localization negative regulation of telomere maintenance via telomere lengthening ATP generation from poly-ADP-D-ribose positive regulation of transcription regulatory region DNA binding telomere maintenance DNA metabolic process base-excision repair transcription, DNA-templated regulation of growth rate cellular response to superoxide regulation of transcription, DNA-templated behavioral response to cocaine regulation of single strand break repair
      Process(es) Blue Arrow Icon
      DNA binding
       DNA ligase (ATP) activity
       NAD+ ADP-ribosyltransferase activity
       protein binding
       transcription factor binding
       zinc ion binding
       enzyme binding
       protein kinase binding
       identical protein binding
       histone deacetylase binding
       poly(A) RNA binding
       protein N-terminus binding
       NAD binding
       R-SMAD binding
       transferase activity, transferring pentosyl groups
       chromatin binding
       transferase activity
       transferase activity, transferring glycosyl groups
       metal ion binding

      Suggested Secondary Antibodies

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