Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
|Tested species reactivity||Human , Mouse , Rat , Cattle|
|Published species reactivity||Mouse , Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The antiserum was produced against a chemically synthesized peptide corresponding to the N-terminus of cleavage site (214/215) of human PARP.|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol|
|Contains||0.05% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||1:500-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss.
||Salker MS,Nautiyal J,Steel JH,Webster Z,Sućurović S,Nicou M,Singh Y,Lucas ES,Murakami K,Chan YW,James S,Abdallah Y,Christian M,Croy BA,Mulac-Jericevic B,Quenby S,Brosens JJ||PloS one (7:null)||2013|
A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924.
44-698G was used in western blot to elucidate resistance to MLN4924.
|Toth JI,Yang L,Dahl R,Petroski MD||Cell reports (1:309)||2012|
CHIR-258: a potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia.
||Lopes de Menezes DE,Peng J,Garrett EN,Louie SG,Lee SH,Wiesmann M,Tang Y,Shephard L,Goldbeck C,Oei Y,Ye H,Aukerman SL,Heise C||Clinical cancer research : an official journal of the American Association for Cancer Research (11:5281)||2005|
Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies.
||Hauerslev S,Sveen ML,Duno M,Angelini C,Vissing J,Krag TO||BMC musculoskeletal disorders (13:null)||2012|
Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice.
||Leemans JC,Juffermans NP,Florquin S,van Rooijen N,Vervoordeldonk MJ,Verbon A,van Deventer SJ,van der Poll T||Journal of immunology (Baltimore, Md. : 1950) (166:4604)||2001|
Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system.
||Markova NG,Karaman-Jurukovska N,Dong KK,Damaghi N,Smiles KA,Yarosh DB||Free radical biology & medicine (46:1168)||2009|
Induction of apoptosis in human lung cancer cells by curcumin.
||Radhakrishna Pillai G,Srivastava AS,Hassanein TI,Chauhan DP,Carrier E||Cancer letters (208:163)||2004|
RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines.
||Cioca DP,Aoki Y,Kiyosawa K||Cancer gene therapy (10:125)||2003|
Peroxisome proliferator-activated receptor gamma ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines.
||Yoshizawa K,Cioca DP,Kawa S,Tanaka E,Kiyosawa K||Cancer (95:2243)||2002|
Proliferation marker pKi-67 affects the cell cycle in a self-regulated manner.
||Schmidt MH,Broll R,Bruch HP,Duchrow M||Journal of cellular biochemistry (87:334)||2002|
Induction of apoptosis and CD10/neutral endopeptidase expression by jaspamide in HL-60 line cells.
||Cioca DP,Kitano K||Cellular and molecular life sciences : CMLS (59:1377)||2002|
ADPRT, Adprt1, parp-1, PARP-1, sPARP-1, Parp-1, C80510, PARP, ARTD1, ADPRT1, pADPRT-1, AI893648, BOS_15645, ADPRT 1, Adprp, RP11-125A15.2, PPOL, Adprt, 5830444G22Rik
ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase), ADP-ribosyltransferase diphtheria toxin-like 1, ADPRT 1, NAD(+) ADP-ribosyltransferase 1, PARP-1, poly (ADP-ribose) polymerase family, member 1, poly [ADP-ribose] polymerase 1, poly(ADP-ribose) synthetase, poly[ADP-ribose] synthase 1, poly[ADP-ribose] synthetase 1, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1, msPARP, ADP-ribosyltransferase (NAD+, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADP-ribosyltransferase 1, poly (ADP-ribose) polymerase), poly(ADP-ribose) polymerase PARP-1, ADP-ribosyltransferase NAD(+), poly(ADP-ribose) polymerase, poly(ADP-ribosyl)transferase, ADPRT, ADPRT1, ARTD1, PPOL, pADPRT-1