|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant human Pax5 protein.|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PAX-5 is a B-cell-specific activator protein (BSAP). In the early stages of B cell developmemt, PAX-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. PAX-5 is expressed in most B-cell malignancies (pre-B and mature B cell lymphomas/leukemias). Over 90% of cases are positive for PAX-5 in Hodgkin's lymphoma, lymphoplasmacytic lymphoma, Merkel cell and small cell carcinoma. T-cell lymphomas, myeloma/plasmacytoma and carcinoid tumors are negative for PAX-5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.