Display Info:
cookie.CK_ISO_CODE.value:fr
cookie.CK_LANG_CODE.value:fr
cookie.CK_DISPLAY_TYPE.value:
pageContext.request:org.apache.struts2.dispatcher.StrutsRequestWrapper@e0340cf
Request attributes: pageContext.request.scheme:http(not used)
syndicationProtocol:http
syndicationExtensionPrefix:
syndicationDisplayType:
      View (7) other PAX6 antibodies

      Invitrogen

      PAX6 Polyclonal Antibody

      Advanced Verification Icon Advanced Verification

      Antibody target was verified by KnockDown to ensure the antibody binds to the antigen stated. View details.

      References Icon 3 References
      DataSheets Icon

      Data Sheets
      Create Citation Icon

      Create Citation
      Tech Support Icon

      Tech Support

       Tech Support Icon

      Tech Support

      Catalog #:42-6600

      Label Icon Check your price
       

      Quantity:

      BulkOrderIcon Bulk order
      Ajouter au panier
      Create your first list

      Usually Ships In 1 business day

      Guarantee Icon Performance Guarantee

      Product Details

      TESTED APPLICATIONS DILUTION
      Flow Cytometry (Flow) 1:100
      Immunocytochemistry (ICC) 2-3 µg/mL
      Immunofluorescence (IF) 2-3 µg/mL
      Immunohistochemistry (Paraffin) (IHC (P)) 1:100
      Western Blot (WB) 1-2 µg/mL
      PUBLISHED APPLICATIONS
      Immunocytochemistry (ICC) See 1 publications below
      Immunoprecipitation (IP) See 1 publications below
      Western Blot (WB) See 1 publications below
      Tested Species reactivity Human, Mouse, Rat
      Published species reactivity Human
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen Human Pax6
      Conjugate Unconjugated
      Form Liquid
      Concentration 0.25 mg/ml
      Purification Affinity chromatography
      Storage buffer PBS, pH 7.4
      Contains 0.1% sodium azide
      Storage conditions -20°C
      RRID AB_2533534

      Product Specific Information

      42-6600 has been successfully used in flow cytometry and immunofluorescence analysis of Pax6 in human neural stem cells derived from pluripotent stem cells and reacts with human samples.

      Background/Target Information

      PAX genes encode nuclear transcription factors which are regarded as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes (aniridia, foveal hypoplasia and Peters and quote; anomaly). Murine PAX genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas.


      All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. PAX6 is involved in the early development of the optical vesicle and has been shown to interact with Six3, another important visual development protein.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (3)

      References Icon

      Have you cited this antibody in a publication? so we can reference it in this datasheet.

      Bioinformatics

      Protein Aliases: AN2; Aniridia; Aniridia Type II Protein; Dickie's small eye; Keratitis; Keratitis); MGDA; Oculorhombin; Paired box 6; paired box gene 6; Paired Box Gene 6 (Aniridia; paired box homeotic gene 6; paired box homeotic gene-6; Paired box protein Pax-6; Paired Box Protein-6; small eye; WAGR

      Gene Aliases: 1500038E17Rik; AEY11; AN; AN2; D11S812E; Dey; FVH1; Gsfaey11; MGDA; Pax-6; PAX6; Sey; WAGR

      UniProt ID: (Human) P26367, (Rat) P63016, (Mouse) P63015

      Entrez Gene ID: (Human) 5080, (Rat) 25509, (Mouse) 18508

      Molecular Function: DNA binding protein helix-turn-helix transcription factor homeobox transcription factor nucleic acid binding transcription factor

      Function(s) Blue Arrow Icon
      negative regulation of transcription from RNA polymerase II promoter establishment of mitotic spindle orientation blood vessel development eye development cell fate determination neuron migration negative regulation of protein phosphorylation positive regulation of neuroblast proliferation lens development in camera-type eye type B pancreatic cell differentiation pancreatic A cell development transcription from RNA polymerase II promoter smoothened signaling pathway axon guidance central nervous system development salivary gland morphogenesis visual perception response to wounding regulation of asymmetric cell division organ morphogenesis dorsal/ventral axis specification positive regulation of gene expression protein ubiquitination oligodendrocyte cell fate specification cerebral cortex regionalization forebrain anterior/posterior pattern specification forebrain dorsal/ventral pattern formation commitment of neuronal cell to specific neuron type in forebrain forebrain-midbrain boundary formation regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment pituitary gland development signal transduction involved in regulation of gene expression keratinocyte differentiation regulation of cell migration positive regulation of epithelial cell differentiation lacrimal gland development protein localization to organelle eye photoreceptor cell development glucose homeostasis negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of timing of cell differentiation embryonic camera-type eye morphogenesis neuron fate commitment astrocyte differentiation negative regulation of epithelial cell proliferation negative regulation of neurogenesis retina development in camera-type eye iris morphogenesis cornea development in camera-type eye negative regulation of neural precursor cell proliferation neural crest cell migration epithelial cell development pancreatic A cell differentiation regulation of transcription from RNA polymerase II promoter axonogenesis brain development negative regulation of cell proliferation anterior/posterior pattern specification dorsal/ventral pattern formation regulation of gene expression regulation of neuron projection development spinal cord development pallium development cerebellum development rhombomere morphogenesis olfactory bulb development telencephalon regionalization interkinetic nuclear migration cell differentiation forebrain development hindbrain development cellular response to insulin stimulus cellular response to drug positive regulation of cell fate specification camera-type eye development cellular response to fibroblast growth factor stimulus cell fate commitment response to ethanol regulation of neuron differentiation regulation of neurogenesis neural precursor cell proliferation positive regulation of glucagon secretion cellular response to glucose stimulus cellular response to prostaglandin E stimulus insulin metabolic process positive regulation of neuron migration transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development
      Process(es) Blue Arrow Icon
      RNA polymerase II core promoter proximal region sequence-specific DNA binding
       RNA polymerase II core promoter sequence-specific DNA binding
       RNA polymerase II transcription factor activity, sequence-specific DNA binding
       transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
       transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
       DNA binding
       chromatin binding
       transcription factor activity, sequence-specific DNA binding
       ubiquitin-protein transferase activity
       protein binding
       transcription factor binding
       protein kinase binding
       ubiquitin protein ligase binding
       histone acetyltransferase binding
       co-SMAD binding
       R-SMAD binding
       HMG box domain binding
       transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
       AT DNA binding
       double-stranded DNA binding
       sequence-specific DNA binding
       transcription regulatory region DNA binding

      Suggested Secondary Antibodies

      Documents

      Material safety data sheets (MSDS)

      Performance Guarantee

      If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*

      We’re here to help

      Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

      Display Info:
      cookie.CK_ISO_CODE.value:fr
      cookie.CK_LANG_CODE.value:fr
      cookie.CK_DISPLAY_TYPE.value:
      pageContext.request.scheme:http(not used)
      syndicationProtocol:http
      syndicationExtensionPrefix:
      syndicationDisplayType:

      We use cookies to ensure that we give you the best experience on our website.

      If you continue without changing your settings, we'll assume that you are happy to receive all cookies on Thermo Fisher Scientific websites. However, you can change your cookie settings at any time at the bottom of this page.

      Continue