This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Western blot analysis of MA1-109 detects an ~47 kDa protein in whole cell lysates from early passage human B3 lens epithelial cells and in mouse eye lysate. An additional unknown band at ~36 kDa is also detected in B3 cell lysates. This antibody will detect additional nonspecific bands in lysates with very low basal PAX6 expression. Specificity of the antibody was confirmed in B3 and mouse eye lysates (positive controls) compared to U-2 OS human osteosarcoma and NIH/3T3 mouse embryonic fibroblasts (negative controls).
MA1-109- can be used for immunofluoresence and flow cytometry analysis of Pax6 in human neural stem cells.
PAX6 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. PAX6 has important functions in the development of the eye, nose, central nervous system and pancreas. Mutations in PAX6 are known to cause ocular disorders such as aniridia and Peter's anomaly. Transcript variants encoding 3 isoforms have been found for this gene, including isoform 1, isoform 5a and isoform 3 (PAX6-5A,6).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AN2; Aniridia; Aniridia Type II Protein; Dickie's small eye; Keratitis; Keratitis); MGDA; Oculorhombin; Paired box 6; paired box gene 6; Paired Box Gene 6 (Aniridia; paired box homeotic gene-6; Paired box protein Pax-6; Paired Box Protein-6; small eye; WAGR
Gene Aliases: 1500038E17Rik; AEY11; AN; AN2; D11S812E; Dey; FVH1; Gsfaey11; MGDA; Pax-6; PAX6; Sey; WAGR