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Invitrogen

PAX6 Recombinant Rabbit Monoclonal Antibody (23GB2875)

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PAX6 Recombinant Rabbit Monoclonal Antibody (23GB2875)

Product Details

MA5-53528

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:1,000
-

Flow Cytometry (Flow)

1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

23GB2875

Immunogen

A synthesized peptide derived from human PAX6 (172-331AA).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3247999

Target Information

This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alternative protein PAX6; Aniridia; Aniridia 1; Aniridia 2; Aniridia type II protein; Keratitis; MGC17209; Oculorhombin; paired box 6 PAX6-12a isoform; paired box 6 PAX6A-ASdel6 isoform; paired box 6 PAX6A-ASdel6-AS7 isoform; paired box 6 PAX6A-del6 isoform; paired box 6 PAX6B-ASdel6 isoform; paired box 6 PAX6D isoform; Paired Box Gene-6; paired box homeotic gene-6; Paired box protein Pax-6; Pax6(S); encoded by transcript variant 4; unnamed protein product

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Gene Aliases: AN; AN1; AN2; ASGD5; D11S812E; FVH1; MGDA; PAX6; WAGR

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UniProt ID: (Human) P26367

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Entrez Gene ID: (Human) 5080

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA binding protein binding protein kinase binding chromatin DNA binding ubiquitin protein ligase binding histone acetyltransferase binding sequence-specific DNA binding co-SMAD binding R-SMAD binding HMG box domain binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter establishment of mitotic spindle orientation blood vessel development eye development cell fate determination neuron migration positive regulation of neuroblast proliferation lens development in camera-type eye regionalization type B pancreatic cell differentiation pancreatic A cell development chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter smoothened signaling pathway nervous system development neuroblast proliferation negative regulation of neuroblast proliferation axonogenesis axon guidance central nervous system development brain development sensory organ development salivary gland morphogenesis visual perception cell proliferation response to wounding anatomical structure morphogenesis regulation of asymmetric cell division organ morphogenesis dorsal/ventral axis specification anterior/posterior pattern specification dorsal/ventral pattern formation gene expression regulation of gene expression positive regulation of gene expression ventral spinal cord development pallium development oligodendrocyte cell fate specification cerebral cortex regionalization forebrain dorsal/ventral pattern formation commitment of neuronal cell to specific neuron type in forebrain forebrain-midbrain boundary formation telencephalon regionalization pituitary gland development habenula development cerebral cortex development signal transduction involved in regulation of gene expression cell differentiation neuron differentiation keratinocyte differentiation regulation of cell migration epithelial cell differentiation positive regulation of epithelial cell differentiation forebrain development lacrimal gland development protein localization to organelle eye photoreceptor cell development glucose homeostasis camera-type eye development cell fate commitment regulation of neuron differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of timing of cell differentiation embryonic camera-type eye morphogenesis neuron fate commitment astrocyte differentiation negative regulation of epithelial cell proliferation regulation of neurogenesis negative regulation of neurogenesis neurological system process retina development in camera-type eye iris morphogenesis cornea development in camera-type eye neural precursor cell proliferation positive regulation of pri-miRNA transcription from RNA polymerase II promoter cellular response to leukemia inhibitory factor negative regulation of neural precursor cell proliferation
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