A suggested positive control for this product is Bosc23 cell lysate transfected with Myc/His/PTPRR.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation.
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Protein Aliases: Ch-1 PTPase; Ch-1PTPase; ECPPT; NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase; protein tyrosine phosphatase, receptor type, R; protein-tyrosine phosphatase NC-PTPCOM1; Protein-tyrosine phosphatase PCPTP1; R-PTP-R; Receptor-type tyrosine-protein phosphatase R
Gene Aliases: EC-PTP; ECPTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ; PTPRR
UniProt ID: (Human) Q15256
Entrez Gene ID: (Human) 5801