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Product Details
H00005122-M02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG3, kappa
Class
Monoclonal
Type
Antibody
Clone
3D2
Immunogen
PCSK1 (NP_000430, 652 a.a. approximately 753 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: GGRRDELEEG APSEAMLRLL QSAFSKNSPP KQSPKKSPTA KLNIPYENFY EALEKLNKPS QLKDSEDSLY NDYVDVFYNT KPYKHRDDRL LQALVDILNE EN
Target Information
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.4.21.93; Furin homolog; NEC 1; Neuroendocrine convertase 1; PC1; PC3; Prohormone convertase 1; prohormone convertase 1/3; prohormone convertase 3; Propeptide-processing protease; Proprotein convertase 1; Protein convertase subtilisin / kexin type I; Protein convertase subtilisin / kexin, type I
Gene Aliases: Att-1; BDP; BMIQ12; Nec-1; NEC1; PC1; PC3; PCSK1; Phpp-1; SPC3
UniProt ID: (Human) P29120, (Rat) P28840, (Mouse) P63239
Entrez Gene ID: (Human) 5122, (Rat) 25204, (Mouse) 18548
proteolysis
cell-cell signaling
metabolic process
protein processing
peptide hormone processing
peptide biosynthetic process
response to glucose
response to inorganic substance
response to chlorate
response to organic cyclic compound
protein autoprocessing
pituitary gland development
neurogenesis
pancreas development
response to nutrient levels
response to lipopolysaccharide
response to drug
response to morphine
response to peptide hormone
response to axon injury
positive regulation of protein secretion
response to glucocorticoid
response to calcium ion
response to fatty acid
response to interleukin-1
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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