|Tested species reactivity||Mouse|
|Host / Isotype||Armenian hamster / IgG|
|Immunogen||PD-1 cDNA transfectant|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||2.0 ug/10^6 cells|
PA5-35011 targets CD279/PD1 in FACS applications and shows reactivity with Mouse samples.
The PA5-35011 immunogen is pD-1 cDNA transfectant.
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of “danger signals” such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.
CD279; hPD-1; hPD-l; PD1; programmed cell death protein 1; programmed cell death protein 1-like; protein PD-1; SLEB2