Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
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Protein Aliases: CD279; hPD-1; hPD-l; mPD-1; PD1; programmed cell death protein 1; protein PD-1; SLEB2
Gene Aliases: Ly101; PD-1; Pdc1
UniProt ID: (Mouse) Q02242
Entrez Gene ID: (Mouse) 18566
Molecular Function: Molecular function unclassified