Proteintech
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:2,000-1:10,000 | View 5 publications 5 publications |
Immunohistochemistry (IHC) |
- | View 9 publications 9 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:500-1:2,000 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:500 | View 1 publication 1 publication |
Flow Cytometry (Flow) |
0.2 µg/1x10^6 cells | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Pig, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
2B11D11 |
Immunogen |
PD-L1/CD274 Fusion Protein Ag12443 (25-241 aa encoded by BC074984) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1.55 mg/mL |
Purification |
Protein G |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: KDLYVVEYG SNMTIECKFP VEKQLDLAAL IVYWEMEDKN IIQFVHGEED LKVQHSSYRQ RARLLKDQLS LGNAALQITD VKLQDAGVYR CMISYGGADY KRITVKVNAP YNKINQRILV VDPVTSEHEL TCQAEGYPKA EVIWTSSDHQ VLSGKTTTTN SKREEKLFNV TSTLRINTTT NEIFYCTFRR LDPEENHTAE LVIPELPLAH PPNERTHL (25-241 aa encoded by BC074984 )
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B7 homolog 1; B7-H1; CD274; CD274 antigen; PD-L1; PDCD1 ligand 1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; sCD274; soluble CD274; soluble PD L1; sPD L1
Gene Aliases: A530045L16Rik; B7-H; B7H1; CD274; PD-L1; PDCD1L1; PDCD1LG1; PDL1; RGD1566211
UniProt ID: (Human) Q9NZQ7, (Mouse) Q9EP73
Entrez Gene ID: (Pig) 574058, (Human) 29126, (Mouse) 60533, (Rat) 499342
Molecular Function:
immunoglobulin receptor superfamily
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