Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).
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Protein Aliases: 3'; 5' cyclic nucleotide phosphodiesterase; 5'-cyclic nucleotide phosphodiesterase 1A; 61 kDa Cam-PDE; calcium/calmodulin-dependent 3'; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; calmodulin-dependent phosphodiesterase; Cam-PDE 1A; hCam-1; HCAM1; HSPDE1A; phosphodiesterase 1A, calmodulin-dependent; phosphodiesterase-1A
Gene Aliases: CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; PDE1A
UniProt ID: (Human) P54750
Entrez Gene ID: (Human) 5136