Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]).
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Protein Aliases: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; DPDE2; PDE4; PDE46; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4
Gene Aliases: DPDE2; PDE4; PDE46; PDE4A
UniProt ID: (Human) P27815
Entrez Gene ID: (Human) 5141