This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
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Protein Aliases: cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; cyclic AMP specific phosphodiesterase PDE4D5A; DPDE1; DPDE3; DPDE4; dunce; dunce-like phosphodiesterase E4; PDE21; PDE32; PDE43; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila); phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); phosphodiesterase E1 dunce homolog; testicular tissue protein Li 136
Gene Aliases: 9630011N22Rik; ACRDYS2; DPDE1; DPDE3; DPDE4; dunce; E130301F19Rik; HSPDE4D; PDE43; PDE4B; PDE4C; PDE4D; PDE4DN2; PDEIVB; R74983; STRK1