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|Tested species reactivity||Human , Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from near the C-terminus of human PDGFR, beta|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 6 publications below|
PA5-16576 targets PDGFR beta in IHC (P) applications and shows reactivity with mouse and Human samples.
The PA5-16576 immunogen is a synthetic peptide derived from near the C-terminus of human PDGFR, beta.
PDGFR (Platelet Derived Growth Factor Receptor) exhibits two different isoforms, alpha and beta coded by two different genes. They possess five immunoglobulin like domains that are involved in ligand binding. Two tyrosine kinase domains are separated by a kinase insert to which PI-3 kinase can bind. PDGF AA can bind autophosphorylate and activate only PDGFR, alpha while PDGF BB can bind and activate to both PDGFR, alpha and beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
New diagnostic markers in salivary gland tumors.
PA5-16576 was used in immunohistochemistry to study the expresion of tumor antigens in order to identify novel diagnostic markers of parotid gland tumors
|Schneider S,Kloimstein P,Pammer J,Brannath W,Grasl MCh,Erovic BM||European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (271:1999)||2014|
Identification of novel target proteins in sebaceous gland carcinoma.
PA5-16576 was used in immunohistochemistry to identify novel therapeutic target proteins in sebaceous gland carcinoma
|Erovic BM,Al Habeeb A,Harris L,Goldstein DP,Kim D,Ghazarian D,Irish JC||Head & neck (35:642)||2013|
Biomarkers of parathyroid carcinoma.
PA5-16576 was used in immunohistochemistry to establish a biomarker panel suitable for the identification of parathyroid carcinomas
|Erovic BM,Harris L,Jamali M,Goldstein DP,Irish JC,Asa SL,Mete O||Endocrine pathology (23:221)||2012|
Prognostic and predictive markers in medullary thyroid carcinoma.
PA5-16576 was used in immunohistochemistry to identify markers with progniostic and predictive value in patients with medullary thyroid cancer
|Erovic BM,Kim D,Cassol C,Goldstein DP,Irish JC,Asa SL,Mete O||Endocrine pathology (23:232)||2012|
The characterization of PDGFR-alpha and PDGFR-beta expression in malignant non-Hodgkin lymphoma.
PA5-16576 was used in immunohistochemistry to study the expression and potential therapeutic significance of PDGFR-alpha and -beta in patients with malignant non-Hodgkin's lymphoma
|Duşe AO,Ceauşu RA,Mezei T,Cîmpean AM,Gaje P,Ioniţă H,Jung I,Raica M||Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (53:749)||2012|
A phase 2 trial of imatinib mesylate in patients with recurrent nonresectable chondrosarcomas expressing platelet-derived growth factor receptor-α or -β: An Italian Sarcoma Group study.
PA5-16576 was used in immunohistochemistry to report a phase 2 clinical trial of imatinib mesylate in the treatment of recurrent nonresectable chondrosarcomas
|Grignani G,Palmerini E,Stacchiotti S,Boglione A,Ferraresi V,Frustaci S,Comandone A,Casali PG,Ferrari S,Aglietta M||Cancer (117:826)||2011|
AI528809, CD140B, PDGFR, CD140b, Pdgfr, IBGC4, PDGFR-1, PDGFR1, JTK12
CD140 antigen-like family member B, PDGF beta chain, PDGF-R-beta, PDGFR-beta, beta platelet-derived growth factor receptor, beta-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor beta, platelet-derived growth factor receptor beta variant 1, PDGF Receptor beta, JTK12, PDGFR, PDGFR1