Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request:org.apache.struts2.dispatcher.StrutsRequestWrapper@5fdb54fe
Request attributes: pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:
syndicationDisplayType:

Proteintech

PDGFRA Monoclonal Antibody (2C11B8)

View all (77) PDGFRA (CD140a) antibodies
Datasheet Created with sketchtool. Datasheet
Protocols Protocols
Questions & Answers Questions & Answers
Tech Support Created with sketchtool. Tech Support
Datasheet Created with sketchtool. Datasheet
Protocols Protocols
Questions & Answers Questions & Answers
Tech Support Created with sketchtool. Tech Support

Product Details

60045-1-IG

Applications Tested Dilution Publications

Western Blot (WB)

 1:2,000-1:20,000 -
Product Specifications

Species Reactivity

 Human

Host/Isotype

 Mouse / IgG1

Class

 Monoclonal

Type

 Antibody

Clone

 2C11B8

Immunogen

PDGFRA Fusion Protein Ag1385 (1-209 aa encoded by BC015186)
View antigen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 0.85 mg/mL

Purification

 Caprylic acid precipitation

Storage buffer

 PBS, pH 7.3, with 50% glycerol

Contains

 0.1% sodium azide

Storage conditions

 -20°C

Product Specific Information

Immunogen sequence: MGTSHPAFL VLGCLLTGLS LILCQLSLPS ILPNENEKVV QLNSSFSLRC FGESEVSWQY PMSEEESSDV EIRNEENNSG LFVTVLEVSS ASAAHTGLYT CYYNHTQTEE NELEGRHIYI YVPDPDVAFV PLGMTDYLVI VEDDDSAIIP CRTTDPETPV TLHNSEGVVP ASYDSRQGFN GTFTVGPYIC EATVKGKKFQ TIPFNVYALK (1-209 aa encoded by BC015186)

Target Information

PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a; CD140a antigen; MGC74795; OTTHUMP00000218656; PDGF A-chain; PDGF Receptor alpha; PDGF-R-alpha; PDGFR-2; pdgfr-a; PDGFRA/BCR fusion; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; Platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor, alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein

Gene Aliases: CD140A; GAS9; PDGFR-2; PDGFR2; PDGFRA; RHEPDGFRA

UniProt ID: (Human) Q9UD28

Entrez Gene ID: (Human) 5156

Molecular Function: transmembrane signal receptor

Function(s)
MAPK cascade luteinization cell activation positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation negative regulation of platelet activation positive regulation of phospholipase C activity regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling viral process peptidyl-tyrosine phosphorylation positive regulation of cell migration cellular response to reactive oxygen species platelet-derived growth factor receptor-alpha signaling pathway positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway wound healing positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity positive regulation of DNA replication protein autophosphorylation phosphatidylinositol phosphorylation platelet-derived growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of fibroblast proliferation embryonic digestive tract morphogenesis embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis regulation of chemotaxis cardiac myofibril assembly cell chemotaxis retina vasculature development in camera-type eye positive regulation of ERK1 and ERK2 cascade platelet aggregation metanephric glomerular capillary formation regulation of actin cytoskeleton reorganization regulation of mesenchymal stem cell differentiation
Process(es)
protein kinase activity transmembrane receptor protein tyrosine kinase activity platelet-derived growth factor alpha-receptor activity vascular endothelial growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity platelet-derived growth factor receptor binding protein binding ATP binding vascular endothelial growth factor binding protein homodimerization activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity platelet-derived growth factor binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support
Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:
syndicationDisplayType: