This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
MA5-15705 targets EIF2AK3 in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15705 immunogen is purified recombinant fragment of human EIF2AK3 expressed in E. Coli.
MA5-15705 detects EIF2AK3 which has a predicted molecular weight of approximately 125kDa.
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 126.96.36.199; Eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase
Gene Aliases: EIF2AK3; PEK; PERK; WRS
UniProt ID: (Human) Q9NZJ5
Entrez Gene ID: (Human) 9451
Molecular Function: non-receptor serine/threonine protein kinase