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|Tested species reactivity||Human|
|Host / Isotype||E.coli|
|Storage buffer||TBS, pH 8.0, with 50% glycerol, 5mM DTT, 0.05% Tween 20|
|Tested Applications||Dilution *|
|Control (Ctrl)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PEST also known as Tyrosine-protein phosphatase, non-receptor type 12 (PTPN12), Protein-tyrosine phosphatase G1 or PTPG1 is a protein-tyrosine phosphatase (PTP) involved in regulating the Wiskott-Aldrich syndrome protein (WASp). WASp is tyrosine dephosphorylated by (PTP)-PEST via proline, serine, threonine phosphatase interacting protein (PSTPIP)1 binding. PTP-PEST combined with PSTPIP1 inhibits WASp-driven actin polymerization and synapse formation. PTP-PEST plays a central role in regulating WASp and is absolutely required for WASp contributions to T cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
protein-tyrosine phosphatase G1; PTPN12
PTP-PEST; PTPG1; PTPN12