Invitrogen

PF4 Monoclonal Antibody (C2)

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PF4 Antibody in Western Blot (WB) — Western blot analysis of PF4 in Human Placenta lysate. Samples were incubated with monoclonal antibody (Product # MA5-41661) at a dilution of 3 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG using a dilution of 0.2 µg/mL.

Product Details

MA5-41661

Applications	Tested Dilution	Publications
Western Blot (WB)	0.5-2 µg/mL	-
Immunohistochemistry (Paraffin) (IHC (P))	5-20 µg/mL	-
Immunocytochemistry (ICC/IF)	5-20 µg/mL	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Mouse / IgG
Class	Monoclonal
Type	Antibody
Clone	C2
Immunogen	Recombinant protein Platelet Factor 4
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein A/G
Storage buffer	PBS with 50% glycerol
Contains	0.05% Proclin 300
Storage conditions	-20°C

Target Information

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; Endothelial cell growth inhibitor; Iroplact; Oncostatin-A; PF-4; Platelet factor 4; Platelet factor 4, short form

Gene Aliases: CXCL4; PF-4; PF4; SCYB4

UniProt ID: (Human) P02776

Entrez Gene ID: (Human) 5196

Molecular Function: chemokine