Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Antibody detects endogenous levels of total PFKFB1/4.
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; 6PF-2-K/Fru-2,6-P2ASE testis-type isozyme; bifunctional enzyme with kinase and biphosphatase activities; fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase; PFK-2/FBPase-2 gene A; PFK/FBPase 1; PFK/FBPase 4
Gene Aliases: C230090D14; F6PK; HL2K; PFK/FBPase 1; Pfkfb01; PFKFB1; PFKFB4; PFRX
UniProt ID: (Human) P16118, (Human) Q16877, (Mouse) P70266, (Rat) P07953, (Rat) P25114, (Mouse) Q6DTY7
Entrez Gene ID: (Human) 5207, (Human) 5210, (Mouse) 18639, (Rat) 24638, (Rat) 54283, (Mouse) 270198
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support