This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.
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Protein Aliases: 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; 6PF-2-K/Fru-2,6-P2ASE testis-type isozyme; bifunctional enzyme with kinase and biphosphatase activities; Fructose-2,6-bisphosphatase; fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase; PFK-2/FBPase-2 gene A; PFK/FBPase 1; PFK/FBPase 4
Gene Aliases: C230090D14; F6PK; HL2K; PFK/FBPase 1; Pfkfb01; PFKFB1; PFKFB4; PFRX