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|Tested species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 182-211 amino acids from the C-terminal region of human PHB1|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
This antibody is predicted to react with bovine, mouse and rat based on sequence homology.
Prohibitin is an evolutionarily conserved protein that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium.
PA5-12274 was used in western blot to elucidate the disruption of short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium due to haploinsufficiency of the 22q11.2 microdeletion gene MrpI40
|Devaraju P,Yu J,Eddins D,Mellado-Lagarde MM,Earls LR,Westmoreland JJ,Quarato G,Green DR,Zakharenko SS||Molecular psychiatry (null:null)||2016|
epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; PHB; Prohibitin
HEL-215; HEL-S-54e; PHB; PHB1