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Abnova
PHB1 Recombinant Rabbit Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
RAB01378
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to human PHB1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 150mM NaCl, 0.05% BSA, 40% glycerol
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; gastric cancer susceptibility protein; OTTHUMP00000165765; OTTHUMP00000165766; OTTHUMP00000220103; OTTHUMP00000220170; OTTHUMP00000220171; PHB; prohibitin; unnamed protein product
Gene Aliases: BAP32; HEL-215; HEL-S-54e; PHB
UniProt ID: (Human) P35232
Entrez Gene ID: (Human) 5245
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
positive regulation of immunoglobulin production
regulation of transcription, DNA-templated
mitochondrion organization
signal transduction
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of cell growth
positive regulation of interleukin-17 production
RIG-I signaling pathway
regulation of gene expression, epigenetic
B cell activation
negative regulation of protein catabolic process
regulation of apoptotic process
positive regulation of neuron apoptotic process
modulation by host of viral RNA genome replication
positive regulation of G-protein coupled receptor protein signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of complement activation
viral entry into host cell
positive regulation of smooth muscle cell proliferation
protein stabilization
progesterone receptor signaling pathway
positive regulation of protein kinase B signaling
negative regulation of androgen receptor signaling pathway
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to interleukin-6
T-helper 17 type immune response
antiviral innate immune response
positive regulation of NIK/NF-kappaB signaling
negative regulation of glucocorticoid receptor signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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