Sequence of this protein is as follows: PVGCSQLLKE SEKPLQTGLP TGLTENQSGG PLGVDSPSAE LDKKANLLKC EYCGKYAPAE QFRGSKRFCS MTCAKRYNVS CSHQFRLKRK KMKEFQEANY *
Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development. PHC1 (polyhomeotic homolog 1), also known as EDR1, HPH1 or RAE28, is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Existing as a homodimer, PHC1 contains one FCS-type zinc finger and a SAM (sterile alpha motif) domain. PHC1 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.
Protein Aliases: DKFZp686A1782; early development regulator 1 (homolog of polyhomeotic 1); Early development regulatory protein 1; hPH1; polyhomeotic-like 1; Polyhomeotic-like protein 1
Gene Aliases: EDR1; HPH1; MCPH11; PH1; PHC1; RAE28
UniProt ID: (Human) P78364
Entrez Gene ID: (Human) 1911
Molecular Function: chromatin/chromatin-binding, or -regulatory protein