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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 531-560 amino acids from the N-terminal region of human PHLPP1|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with mouse and rat based on sequence homology.
PHLPP1 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
EC 184.108.40.206; hSCOP; KIAA0606; PH domain leucine-rich repeat-containing protein phosphatase; PH domain-containing family E member 1; PHLPP; PHLPP1; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; Pleckstrin homology domain-containing family E protein 1; PLEKHE1; protein phosphatase, Mg2+/Mn2+ dependent 3A; SCN circadian oscillatory protein; SCOP; suprachiasmatic nucleus circadian oscillatory protein
KIAA0606; PHLPP; PHLPP1; PLEKHE1; PPM3A; SCOP