|Flow Cytometry (Flow)||1:10-1:50|
|Western Blot (WB)||1:1000|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 1295-1323 amino acids from the C-terminal region of human PHLPP2|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PHLPP2 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1. This protein regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decrease cell proliferation. It also controls the phosphorylation of AKT3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like; PHLPPL; protein phosphatase, Mg2+/Mn2+ dependent 3B
Gene Aliases: KIAA0931; PHLPP2; PHLPPL; PPM3B
UniProt ID: (Human) Q6ZVD8
Entrez Gene ID: (Human) 23035
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