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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human PINCH expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/200 - 1/400|
|Immunofluorescence (IF)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15876 targets PINCH in FACS, IF, and WB applications and shows reactivity with Human samples.
The MA5-15876 immunogen is purified recombinant fragment of human PINCH expressed in E. Coli. .
MA5-15876 detects PINCH which has a predicted molecular weight of approximately 37kDa.
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
LIM and senescent cell antigen-like domains 1; LIM-type zinc finger domains 1; particularly interesting new Cys-His protein 1; PINCH, PINCH-1, PINCH1, LIM and senescent cell antigen-like-containing domain protein 1; renal carcinoma antigen NY-REN-48; senescent cell antigen
LIMS1; PINCH; PINCH-1; PINCH1