Immunogen sequence: MSSNCTSTTA VAVAPLSASK TKTKKKHFVC QKVKLFRASE PILSVLMWGV NHTINELSNV PVPVMLMPDD FKAYSKIKVD NHLFNKENLP SRFKFKEYCP MVFRNLRERF GIDDQDYQNS VTRSAPINSD SQGRCGTRFL TTYDRRFVIK TVSSEDVAEM HNILKKYHQF IVECHGNTLL PQFLGMYRLT VDGVETYMVV TRNVFSHRLT VHRKYDLKGS TVAREASDKE KAKDLPTFKD NDFLNEGQKL HVGEESKKNF LEKLKRDVEF; Positive Samples: BT-474, HepG2, A-549; Cellular Location: Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Nucleus, Peripheral membrane protein
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.
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Protein Aliases: 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; 1-phosphatidylinositol-5-phosphate 4-kinase B; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; phosphatidylinositol-5-phosphate 4-kinase type-2 beta; phosphatidylinositol-5-phosphate 4-kinase, type II, beta; Phosphatidylinositol-phosphate kinase IIgamma; PI(5)P 4-kinase type II beta; PIP4KII-beta; PIPKIIgamma; PTDINS(4)P-5-kinase; PtdIns(5)P-4-kinase isoform 2-beta
Gene Aliases: AI848124; c11; PI5P4KB; PI5P4Kbeta; PIP4K2B; PIP5K2B; PIP5KIIB; PIP5KIIbeta; PIP5P4KB