Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, mouse brain.
Predicted reactivity: Mouse (94%), Rat (94%), Chicken (95%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Phosphatidylinositol-4-phosphate-5-kinase (PIPK) synthesizes phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking and cytoskeletal organization. The PIPK family is divided into type I, type II and type III. Each type of the PIPK family phosphorylates distinct substrates. They contain an activation loop, which determines their enzymatic specificity and subcellular targeting. The phosphatidylinositol-4-phosphate-5-kinase type I consists of three members, PIPK I alpha, beta and gamma, which are characterized by phosphorylating PI4P on the 5-hydroxyl. PIPK I alpha, designated PIPK I beta in mouse, is expressed in brain tissue. PIPK I beta, designated PIPK I alpha in mouse, is also called STM7. PIPK I gamma has two variants produced by alternative splicing which are expressed in lung, brain and kidneys.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: diphosphoinositide kinase; Human homolog of mouse phosphatidylinositol-4-phosphate 5-kinase I-gamma; LCCS3; Phosphatidylinositol 4-phosphate 5-kinase type I gamma; Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; phosphatidylinositol-4-phosphate 5-kinase type I gamma; phosphatidylinositol-4-phosphate 5-kinase type-1 gamma; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; PIP5K-GAMMA; PIP5K1-gamma; PIP5Kgamma; PIP5KIgamma; PIPKIg_v4; ptdIns(4)P-5-kinase 1 gamma; type I PIP kinase
Gene Aliases: AI115456; AI835305; KIAA0589; LCCS3; PIP5K-GAMMA; PIP5K1-gamma; PIP5K1C; PIP5Kgamma; Pip5kIgamma