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Product Details
66429-1-IG
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Pig, Rat |
Host/Isotype |
Mouse / IgG2a |
Class |
Monoclonal |
Type |
Antibody |
Clone |
2F4B9 |
Immunogen |
PKC gamma Fusion Protein Ag5910 (351-697 aa encoded by BC047876) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: FSFLMVLGK GSFGKVMLAE RRGSDELYAI KILKKDVIVQ DDDVDCTLVE KRVLALGGRG PGGRPHFLTQ LHSTFQTPDR LYFVMEYVTG GDLMYHIQQL GKFKEPHAAF YAAEIAIGLF FLHNQGIIYR DLKLDNVMLD AEGHIKITDF GMCKENVFPG TTTRTFCGTP DYIAPEIIAY QPYGKSVDWW SFGVLLYEML AGQPPFDGED EEELFQAIME QTVTYPKSLS REAVAICKGF LTKHPGKRLG SGPDGEPTIR AHGFFRWIDW ERLERLEIPP PFRPRPCGRS GENFDKFFTR AAPALTPPDR LVLASIDQAD FQGFTYVNPD FVHPDARSPT SPVPVPVM (351-697 aa encoded by BC047876)
Target Information
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PKC-gamma; Protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma
Gene Aliases: PKC; PKC-gamma; PKCC; PKCG; PKCgamma; PKCI; Prkc; Prkcc; PRKCG; RATPKCI; SCA14
UniProt ID: (Human) P05129, (Mouse) P63318, (Rat) P63319
Entrez Gene ID: (Human) 5582, (Pig) 100518074, (Mouse) 18752, (Rat) 24681
Molecular Function:
non-receptor serine/threonine protein kinase
protein phosphorylation
chemical synaptic transmission
learning or memory
chemosensory behavior
phosphorylation
peptidyl-serine phosphorylation
platelet activation
negative regulation of protein ubiquitination
regulation of response to food
positive regulation of mismatch repair
intracellular signal transduction
negative regulation of protein catabolic process
regulation of circadian rhythm
response to morphine
negative regulation of neuron apoptotic process
protein autophosphorylation
response to pain
rhythmic process
regulation of phagocytosis
innervation
negative regulation of proteasomal protein catabolic process
protein kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein serine/threonine/tyrosine kinase activity
ATP binding
zinc ion binding
nucleotide binding
protein serine/threonine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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