Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: atypical protein kinase C; EC 18.104.22.168; kinase PKC-zeta; KPCZ; nPKC-zeta; PKC-zeta; PRKCZ; protein kinase C zeta subspecies; Protein kinase C zeta type
Gene Aliases: AI098070; aPKCzeta; C80388; nPKC-zeta; Pkcz; Prkcz; R74924; zetaPKC
UniProt ID: (Mouse) Q02956
Entrez Gene ID: (Mouse) 18762
Molecular Function: annexin calcium-binding protein calmodulin intracellular calcium-sensing protein kinase non-receptor serine/threonine protein kinase protein kinase transfer/carrier protein transferase