This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA5-15887 targets PRK2 in FACS, IHC, and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.
The MA5-15887 immunogen is purified recombinant fragment of human PRK2 expressed in E. Coli. .
MA5-15887 detects PRK2 which has a predicted molecular weight of approximately 140kDa.
Protein-kinase-C-related kinases (PRKs) are part of the lipid-regulated protein kinases (PKC) which also include liver PAK and PKN. Human PRK1 and PRK2 share structurally similar catalytic domains, but less similar N-terminal regulatory regions suggesting different regulatory domain functions. PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in adult tissues. Additionally, the serine-threonine kinase PRK2 can be specifically cleaved by caspase-3 (and/or caspase-3-like subfamily members) during apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cardiolipin-activated protein kinase Pak2; p140 kinase; PKN gamma; protease-activated kinase 2; Protein kinase C-like 2; Protein-kinase C-related kinase 2; RP5-905H16.1, PAK2, PRK2, PRKCL2, PRO2042, Pak-2, cardiolipin-activated protein kinase Pak2; serine/threonine kinase 7; Serine/threonine-protein kinase N2
Gene Aliases: 6030436C20Rik; AI507382; Pak-2; PAK2; PKN2; PRK2; PRKCL2; PRO2042; STK7
Molecular Function: annexin calcium-binding protein calmodulin intracellular calcium-sensing protein kinase non-receptor serine/threonine protein kinase protein kinase transfer/carrier protein transferase