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Product Details
MA5-24282
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
2 µg/mL | - |
Immunoprecipitation (IP) |
25 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2A |
Class |
Monoclonal |
Type |
Antibody |
Clone |
630823 |
Immunogen |
Mouse myeloma cell line NS0-derived recombinant human PLA2G1B Met1-Ser148 |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Concentration |
0.5 mg/mL |
Purification |
Protein A/G |
Storage buffer |
PBS with 5% trehalose |
Contains |
No Preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2609764 |
Product Specific Information
In direct ELISAs, no cross-reactivity with recombinant human (rh) PLA2G2A, rhPLA2G7, recombinant mouse (rm) PLA2G2A, or rmPLA2R1 is observed.
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
Phospholipase A2 catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Group IB phospholipase A2; MGC119834; MGC119835; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; phospholipase A2, group IB (pancreas)
Gene Aliases: PLA2; PLA2A; PLA2G1B; PPLA2
UniProt ID: (Human) P04054
Entrez Gene ID: (Human) 5319
Molecular Function:
phospholipase
activation of MAPK activity
innate immune response in mucosa
neutrophil mediated immunity
fatty acid biosynthetic process
phosphatidic acid biosynthetic process
actin filament organization
signal transduction
positive regulation of calcium ion transport into cytosol
glucose transport
leukotriene biosynthetic process
antibacterial humoral response
neutrophil chemotaxis
activation of phospholipase A2 activity
interleukin-8 production
cellular response to insulin stimulus
intracellular signal transduction
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
multicellular organism lipid catabolic process
positive regulation of DNA replication
positive regulation of transcription from RNA polymerase II promoter
phosphatidylcholine metabolic process
positive regulation of fibroblast proliferation
arachidonic acid secretion
positive regulation of protein secretion
positive regulation of immune response
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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