Positive Control: 293T, A431, HeLa
Predicted Reactivity: Zebrafish (89%), Xenopus laevis (91%), Chicken (95%), Rhesus Monkey (100%), Bovine (99%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Phospholipid scramblases (PLS) translocate phospholipids bidirectionally between inner and outer leaflets of the plasma membrane and are implicated in apoptosis (1,2). Members of this family, PLS1 and PLS3 are both substrates of Protein kinase C (PKC) delta and are phosphorylated by PKC-delta during apoptosis. PKC-delta translocates to mitochondria during apoptosis and phosphorylates PLS3. Overexpression of PLS3 in the HEK293 cells enhanced apoptosis induced by UV-irradiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: plastin 3 (T-isoform); plastin 3, T; Plastin-3; T fimbrin; T plastin; T-plastin
Gene Aliases: AI115446; AL024105; BMND18; PLS3; T-fimbrin; T-plastin