The antibody 13A6 [TEC-23] binds to rat Phospholipid Scramblase 1 (PLSCR1), an 37-49 kDa membrane-associated protein accelerating bidirectional movement of plasma membrane phospholipids during conditions of elevated calcium.
Western Blot: Both reducing and non-reducing conditions.
The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.
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Protein Aliases: Ca(2+)-dependent phospholipid scramblase 1; Mg(2+)-dependent nuclease; Phospholipid scramblase 1; phospholipid scramblase 2; PL scramblase 1
Gene Aliases: Plscr1
UniProt ID: (Rat) P58195
Entrez Gene ID: (Rat) 117540
Molecular Function: transporter