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Invitrogen
PLSCR1 Recombinant Rabbit Monoclonal Antibody (ARC2028)
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
Product Details
MA5-38066
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC2028
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Phospholipid Scramblase 1 (PLSCR1) (NP_0669281)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.61 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897984
Product Specific Information
Positive Samples: HT-29, Mouse lung
Immunogen sequence: MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE
Target Information
The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; Mg(2+)-dependent nuclease; MmTRA1b; NOR1; Phospholipid scramblase 1; phospholipid scramblase 2; PL scramblase 1; Transplantability-associated protein 1
Gene Aliases: MmTRA1a; MMTRA1B; Nor1; PLSCR1; Tra1; Tra1a; Tra1b; Tras1; Tras2
UniProt ID: (Human) O15162, (Rat) P58195, (Mouse) Q9JJ00
Entrez Gene ID: (Human) 5359, (Rat) 117540, (Mouse) 22038
transcription from RNA polymerase II promoter
phosphatidylserine biosynthetic process
apoptotic process
acute-phase response
positive regulation of gene expression
phospholipid scrambling
platelet activation
regulation of mast cell activation
response to interferon-beta
negative regulation of viral genome replication
positive regulation of innate immune response
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
regulation of Fc receptor mediated stimulatory signaling pathway
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
immune response
phospholipid transport
myeloid cell differentiation
negative regulation of protein binding
response to interferon-alpha
positive regulation of apoptotic process
phosphatidylserine exposure on apoptotic cell surface
cellular response to lipopolysaccharide
cellular response to cytokine stimulus
intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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