A suggested positive control for immunohistochemical applications is melanoma. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Melanoma gp100 a melanosomal matrix protein whose expression is closely correlated with cellular melanin content and which is a frequent melanoma tumor antigen recognized by cytotoxic T lymphocytes. It is a likely candidate gene for some cases of human oculocutaneous albinism not associated with known albinism loci.
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Protein Aliases: 95 kDa melanocyte-specific secreted glycoprotein; D12S53E, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100,melanocyte protein PMEL; M-alpha; M-beta; ME20-M; ME20-S; ME20M; melanocyte protein mel 17; Melanocyte protein PMEL; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; melanosomal matrix protein17; P1; P100; P26; Premelanosome protein; Secreted melanoma-associated ME20 antigen; Silver locus protein homolog; silver, mouse, homolog of
Gene Aliases: D12S53E; gp100; ME20; ME20-M; ME20M; P1; P100; PMEL; PMEL17; SI; SIL; SILV
UniProt ID: (Human) P40967
Entrez Gene ID: (Human) 6490