Invitrogen

PMEL Monoclonal Antibody (HMB45)

Product Details

Tested Applications

Dilution

Immunocytochemistry (ICC)

Assay-dependent

Immunofluorescence (IF)

Assay dependent

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

Published Applications

Miscellaneous PubMed (MISC)

See 1 publication below

Immunohistochemistry (Paraffin) (IHC (P))

See 2 publications below

Western Blot (WB)

See 5 publications below

Immunohistochemistry (IHC)

See 15 publications below

Immunocytochemistry (ICC)

See 12 publications below

Neutralization (Neu)

See 1 publication below

Product Specifications

Species Reactivity

Human

Published species

Bovine, Human, Mouse

Host / Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

HMB45

Immunogen

The extract of pigmented melanoma metastases from lymph nodes.

Conjugate

Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C, do not freeze

RRID

AB_1955861

Product Specific Information

This antibody reacts with an antigen present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells.This antibody reacts with melanomas and tumors showing melanoma/melanocytic differentiation. It reacts with junctional and blue nevus cells. Non-melanocytic cells do not react with this antibody.

Target Information

Melanoma is a malignant tumor of melanocytes which are found predominantly in skin but also in the bowel and the eye (see uveal melanoma). It is one of the rarer types of skin cancer but causes the majority of skin cancer related deaths.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 95 kDa melanocyte-specific secreted glycoprotein; M-alpha; M-beta; ME20-M; ME20-S; ME20M; melanocyte protein mel 17; Melanocyte protein PMEL; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; melanosomal matrix protein17; P1; P100; P26; Premelanosome protein; Secreted melanoma-associated ME20 antigen; Silver locus protein homolog; silver, mouse, homolog of

Gene Aliases: D12S53E; gp100; ME20; ME20-M; ME20M; P1; P100; PMEL; PMEL17; SI; SIL; SILV

UniProt ID: (Human) P40967

Entrez Gene ID: (Human) 6490

Molecular Function: cell adhesion molecule membrane-bound signaling molecule signaling molecule