Sequence of this protein is as follows: RDPIDVDLDV SNTTTAQKRK CSQTQCPRKV IKMESEEGKE ARLARSSPEQ PRPSTSKAVS PPHLDGPPSP RSPVIGSEVF LPNSNHVASG AGEAEERVVV
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
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Protein Aliases: E3 SUMO-protein ligase PML; PML/RARA fusion; pml1; probable transcription factor PML; promyelocytic leukemia; Promyelocytic leukemia protein; promyelocytic leukemia, inducer of; Protein PML; RING finger protein 71; RING-type E3 SUMO transferase PML; TRIM19; tripartite motif protein TRIM19; Tripartite motif-containing protein 19
Gene Aliases: MYL; PML; PP8675; RGD1562602; RNF71; TRIM19
UniProt ID: (Human) P29590