|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
|Western Blot (WB)||Assay-Dependent|
|Species reactivity||Human, Non-human primate|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Human PMP22 cDNA boosted with a 13-amino acid peptide, conjugated to murine IgG.|
|Storage buffer||tris glycine with 150mM NaCl|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Suggested positive control: fetal spinal cord.
Peripheral Myelin Protein 22 (PMP22) is a 160 amino acid glycoprotein which is a member of the claudin family and is thought to play an important role in the structure of peripheral nerve myelin. Irregularities in its gene results in hereditary demyelinating neuropathies. PMP22 protein is present in the compact myelin of adult human peripheral nerve and its distribution mimics that of Myelin Protein zero (P0).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GAS-3; Growth arrest-specific protein 3; Peripheral myelin protein 22; peripheral myelin protein 22 kDa; PMP-22
Gene Aliases: CMT1A; CMT1E; DSS; GAS-3; GAS3; HMSNIA; HNPP; PMP22; Sp110
UniProt ID: (Human) Q01453
Entrez Gene ID: (Human) 5376
Molecular Function: cytoskeletal protein
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