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Product Details
CF502822
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI1D2
Immunogen
Full length human recombinant protein of human PNMT produced in HEK293T cell.
Conjugate
Unconjugated
Form
lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Noradrenaline N-methyltransferase; phenylethanolamine N-methylase; Phenylethanolamine N-methyltransferase; PNMTase
Gene Aliases: PENT; PNMT; PNMTase
UniProt ID: (Human) P11086, (Mouse) P40935, (Rat) P10937
Entrez Gene ID: (Human) 5409, (Dog) 491023, (Mouse) 18948, (Rat) 24661
Molecular Function:
methyltransferase
methylation
epinephrine biosynthetic process
catecholamine biosynthetic process
norepinephrine metabolic process
response to hypoxia
response to cold
response to water deprivation
response to activity
adrenal gland development
response to corticosteroid
response to insulin
social behavior
response to isolation stress
response to immobilization stress
response to peptide hormone
response to ethanol
response to ether
S-adenosylhomocysteine metabolic process
S-adenosylmethionine metabolic process
sensory perception of taste
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
cellular response to dexamethasone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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