|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||17 amino acid peptide near the carboxy terminus of human POU2F3|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||20 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A recommended positive control is SK-N-SH cell lysate.
At least two isoforms are known to exist; this antibody will recognize both isoforms. POU2F3 antibody is not expected to cross-react with other members of the POU domain class 2 family.
POU2F3, also known as Epoc-1, is a member of a family of POU domain family of transcription factors. POU2F3 is expressed primarily in the epidermis and plays a critical role in keratinocyte proliferation and differentiation. It is a crucial transcription factor that is required for the development of sweet, umami, and bitter, but not sour taste receptor cells. POU2F3 is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.