MA5-15589 targets PPP1A in WB applications and shows reactivity with Human and mouse samples.
The MA5-15589 immunogen is purified recombinant fragment of human PPP1A expressed in E. Coli.
MA5-15589 detects PPP1A which has a predicted molecular weight of approximately 38kDa.
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 . PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: MGC15877; MGC1674; PP-1A; PP1alpha; PPP1A; PPP1CA; protein phosphatase 1, catalytic subunit, alpha isoform; protein phosphatase 1, catalytic subunit, alpha isozyme; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; testicular tissue protein Li 155
Gene Aliases: dism2; PP-1A; PP1A; PP1alpha; PPP1A; Ppp1c; PPP1CA