|Tested species reactivity||Chicken, Fruit fly, Human, Mouse, Non-human primate, Pig, Rat|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids at the carboxy terminus of human PP2A catalytic subunit|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:100|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other PP2A subunits.
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase.
PA5-17510 was used in western blot to study an increase in tau phosphorylation via P38 mitogen-activated protein kinase dye to glucose deprivation
|Lauretti E,Praticò D||Aging cell (14:1067)||2015|
Modulation of AD neuropathology and memory impairments by the isoprostane F2¿ is mediated by the thromboxane receptor.
PA5-17510 was used in western blot to characterize the behavioral, biochemical, and neuropathologic effects of 8ISO in the triple transgenic mouse model of Alzheimer's disease
|Lauretti E,Di Meco A,Chu J,Praticò D||Neurobiology of aging (36:812)||2015|