Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG). Subsequently, multiple isoforms of PAP2 were cloned It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3.
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Protein Aliases: Lipid phosphate phosphohydrolase 1; lipid phosphate phosphohydrolase 1a; LLP1a; LPP1; PAP-2a; PAP2; PAP2-alpha; PAP2a2; PAP2alpha2; PAPalpha1; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; Phosphatidic acid phosphatase type 2A; phosphatidic acid phosphohydrolase type 2a; Phospholipid phosphatase 1; type-2 phosphatidic acid phosphatase alpha
Gene Aliases: LLP1a; LPP1; PAP-2a; PAP2; PLPP1; PPAP2A
UniProt ID: (Human) O14494
Entrez Gene ID: (Human) 8611