The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. This protein is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosynthesis. This gene and PAICS/AIRC, a bifunctional enzyme catalyzing steps six and seven in the purine nucleotide biosynthesis pathway, are located in close proximity on chromosome 4.
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Protein Aliases: Amidophosphoribosyltransferase; ATase; EC 22.214.171.124; glutamine phosphoribosylpyrophosphatate amidotransferase; Glutamine phosphoribosylpyrophosphate amidotransferase; glutamine PRPP amidotransferase; GPAT
Gene Aliases: 5730454C12Rik; AA408689; AA675351; AI507113; ATASE; C79945; GPAT; PPAT; PRAT
Molecular Function: transferase