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Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
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Protein Aliases: Calpromotin; epididymis secretory sperm binding protein Li 2a; HGNC:9353; MGC4104; Natural killer cell-enhancing factor B; NKEF-B; Peroxiredoxin-2; protector protein; PRP; Prx II-1; thiol specific antioxidant protein; thiol-specific antioxidant 1; Thiol-specific antioxidant protein; thioredoxin dependent peroxide reductase 1; Thioredoxin peroxidase 1; thioredoxin reductase; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2; torin; Trx dependent peroxide reductase 1; TSA
Gene Aliases: AL022839; Band-8; HEL-S-2a; NKEF-B; NKEFB; PRDX2; PRP; PRX2; PRXII; PTX1; TDPX1; TDX1; Torin; TPx; TPx-B; TPX1; TR; TSA
Molecular Function: peroxidase