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Product Details
TA501684
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI4F1
Immunogen
Full length human recombinant protein of human PRKD2 produced in HEK293T cell.
Conjugate
Unconjugated
Form
liquid
Concentration
0.89 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Target Information
PRKD2 (PKD2) is a member of the protein kinase D serine/threonine protein kinase family. PRKD2 is a component in the signal transduction pathway induced by phorbol esters and the CCK b gastrin receptor. It exhibits the strongest homology to the serine threonine protein kinases PKD/PKC and PKCnu, particularly in the duplex zinc finger-like cysteine-rich motif, in the pleckstrin homology domain and in the protein kinase domain. In contrast, it shows only a low degree of sequence similarity to other members of the PKC family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: nPKC-D2; Serine/threonine-protein kinase D2
Gene Aliases: HSPC187; nPKC-D2; PKD2; PRKD2
UniProt ID: (Human) Q9BZL6
Entrez Gene ID: (Human) 25865
Molecular Function:
non-receptor serine/threonine protein kinase
angiogenesis
positive regulation of endothelial cell proliferation
adaptive immune response
protein phosphorylation
cell adhesion
cell death
positive regulation of endothelial cell migration
peptidyl-serine phosphorylation
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of interleukin-2 production
positive regulation of interleukin-8 production
positive regulation of CREB transcription factor activity
positive regulation of peptidyl-serine phosphorylation
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
positive regulation of blood vessel endothelial cell migration
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
endothelial tube morphogenesis
positive regulation of ERK1 and ERK2 cascade
protein kinase D signaling
mitophagy in response to mitochondrial depolarization
positive regulation of histone deacetylase activity
positive regulation of intracellular signal transduction
positive regulation of DNA biosynthetic process
positive regulation of endothelial cell chemotaxis
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