NeoBiotechnologies

PRMT6 Monoclonal Antibody (PCRP-PRMT6-2C9)

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PRMT6 Antibody in Flow Cytometry (Flow) — Flow Cytometry analysis of PFA-fixed HeLa cells using PRMT6 Monoclonal Antibody (Product # 55170-MSM2-P1) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).

PRMT6 Antibody in Peptide array (ARRAY) — Analysis of Protein Array containing more than 19,000 full-length human proteins PRMT6 Monoclonal Antibody (Product # 55170-MSM2-P1). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

PRMT6 Antibody — SDS-PAGE Analyis Purified PRMT6 Monoclonal Antibody (Product # 55170-MSM2-P1). Confirmation of Purity and Integrity of Antibody.

Product Details

55170-MSM2-P1

Applications	Tested Dilution	Publications
Flow Cytometry (Flow)	1-2 µg/10^6 cells	-
Peptide Array (Array)	Assay-dependent	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Mouse / IgG2b
Class	Monoclonal
Type	Antibody
Clone	PCRP-PRMT6-2C9
Immunogen	Recombinant full-length human PRMT6 protein View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	200 µg/mL
Purification	Protein A
Storage buffer	PBS, pH 7.4, with 0.05% BSA
Contains	0.05% sodium azide
Storage conditions	4° C

Product Specific Information

This antibody is predicted to react with Rat.

Target Information

Protein arginine N-methyltransferase 6 (PRMT6) PRMT6 demonstrates type I PRMT activity, capable of forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. cts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ10559; FLJ51477; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase-like 6; PRMT-6; Protein arginine N-methyltransferase 6

Gene Aliases: HRMT1L6; PRMT6

UniProt ID: (Human) Q96LA8

Entrez Gene ID: (Human) 55170

Molecular Function: protein modifying enzyme