This antibody recognizes the 95 kDa PSD-95 protein. Cross-reactivity with an unknown protein at ~50 kDa has been observed in western blots with rat brain homogenates. Western blots with mouse brain homogenates did not show such a band.
Positive reactivity of this antibody was confirmed on western blots of rat brain homogenates and lysates of PSD-95- transfected HEK293 (human embryonic kidney) cells.
This gene encodes a member of the membrane-associated guanylate kinase family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: discs large homolog 4; Disks large homolog 4; Dlg4; Post Synaptic Density; post-synaptic density protein 95; Postsynaptic density protein 95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; PSD95; SAP-90; SAP90; Synapse Associated Protein 95 kDa; Synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15
Gene Aliases: DLG4; Dlgh4; PSD-95; PSD95; SAP-90; SAP90; SAP90A