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|Tested species reactivity||Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human PSIP1 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||1/200 - 1/1000|
|Immunohistochemistry (IHC)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15795 targets PSIP1 in IF, IHC, and WB applications and shows reactivity with Human, Non-human primate, and Rat samples.
The MA5-15795 immunogen is purified recombinant fragment of human PSIP1 expressed in E. Coli.
MA5-15795 detects PSIP1 which has a predicted molecular weight of approximately 75kDa.
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CLL-associated antigen KW-7; dense fine speckles 70; Dense fine speckles 70 kDa protein; DFS 70; DFS70, LEDGF, PAIP, PSIP2, p52, p75, CLL-associated antigen KW-7; Lens epithelium-derived growth factor; mLEDGF; PC4 and SFRS1 interacting protein 2; PC4 and SFRS1-interacting protein; supercoiled DNA binding protein 75; transcriptional coactivator p52/p75; Transcriptional coactivator p75/p52
AA408851; AU015605; DFS70; LEDGF; Ledgfa; Ledgfb; p52; p75; PAIP; PSIP1; PSIP2; SBP75